Characterizing Antibodies

Characterizing Therapeutic Monoclonal Antibodies

Introduction Accounting for the inherent heterogeneity of monoclonal antibodies is essential to ensure production of consistent and safe therapeutics and, in light of this, there is an array of chromatographic and supporting regulatory systems. Robust characterization and analysis of monoclonal antibodies is becoming a fast and straightforward process thanks to the myriad technological advances...

Characterizing and engineering antibodies against the epidermal growth factor receptor

Epidermal growth factor receptor (EGFR) signaling leads to cellular proliferation and migration, and thus EGFR dysregulation can significantly contribute to the survival of tumor cells. Aberrant EGFR signaling due to receptor overexpression, mutation, or autocrine ligand has been observed in a wide variety of malignancies, and antibody drugs which inhibit EGFR signaling have been developed. How...

Characterizing sub-topical functions

In this paper, we first give a characterization of sub-topical functions with respect to their lower level sets and epigraph. Next, by using two different classes of elementary functions, we present a characterization of sub-topical functions with respect to their polar functions, and investigate the relation between polar functions and support sets of this class of functions. Finally, we obtai...

Characterizing Physicochemical Properties of Enset Starch

Characterizing the impact of CD8 antibodies on class I MHC multimer binding.

Many studies have suggested that CD8 Abs affect the binding of class I MHC tetramers/multimers to CD8(+) T cells, which has led to the interpretation that CD8 participates directly in multimer binding. In contrast, a recent publication has argued that CD8 Abs instead cause reorganization of TCR distribution and hence have an indirect effect on multimer binding to the TCR alone. We address these...